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essay代写:e -选择素的细胞粘附分子

内皮细胞表达一种叫做e -选择素的细胞粘附分子。在人类中,SELE基因编码e选择素。e -选择素与乳腺癌细胞表达的e -选择素配体特异性结合,通过转化为牢固的粘附[5][6],在乳腺癌细胞与内皮细胞粘附中发挥重要作用。

白细胞在正常炎症和病理性炎症反应后可用于伤口愈合、动脉粥样硬化、炎症性肠病和关节炎等与血管内皮细胞结合。从这个过程,它需要一个事件的情况称为最初的系固,轧制,牢固的粘附和溢出。在第一个初始过程中,循环中的白细胞与内皮细胞相连。这是因为白细胞与红细胞的相互作用。这导致白细胞向血管壁聚集。它们之间最初的接触是由于机械性能。然而,对于栓系过程,白细胞和内皮细胞之间发生相互作用是有先决条件的。在初始的栓系过程中,白细胞向血液流动的方向滚动。它成功地从这个过程中分离出来。滚动行为是独特的,因为速度通常是10至100倍低于白细胞表现出非粘附特性。在此过程中,需要考虑轧制速度。一旦轧制开始,活化的白细胞通过内皮细胞迁移到血管外空间或血管外。对于所有这些过程,都需要白细胞有成功的细胞分子相互作用。因此,结合分子相互作用和白细胞的机械性质是启动这一行动的先决条件。为了进一步了解这种情况的动态,可以使用生物物理学来了解这种情况的细微差别。

人们发现这些细胞的外表面带有负电荷。这就导致了弱胶体键的形成,这是由于静电和弱范德华相互作用的影响。


essay代写 :e -选择素的细胞粘附分子

Endothelial cells express a cell adhesion molecule called E-selectin. In humans, the SELE gene codes E-Selectin. By specificity binding to E-selectin ligands expressed by breast cancer cells, E-selectin plays an important role in adhesion of breast cancer cells to endothelial cells by conversing rolling to firm adhesion[5][6].
Leukocyte in response to normal and pathological inflammation for wound healing, atherosclerosis, inflammatory bowel disease and arthritis binds to the vascular endothelium. From this process, it entails a case of events known as initial tethering, rolling, firm adhesion and extravasation. In the first initial process, the circulating leukocytes tether to the endothelium. This is because of the leucocytes interaction with the erythrocytes. This leads to the leukocytes to be concentrated towards the vessel wall. The first initial contact between them is because of the mechanical properties. Nevertheless, for the tethering process, there is a prerequisite for the interaction to occur between leukocytes and the endothelium. After the process of initial tethering, the leucocytes roll in the direction of blood flow in the system. It successfully detaches itself from this process. The rolling behavior is uniquely owing to the velocity that is typically 10 to 100 fold lower than leucocytes exhibiting non-adherence characteristic. In this process, there is a need to factor in the rolling velocity. Once rolling is initiated, the activated leucocytes migrate across the endothelium to the extravascular space or the extravasation. For all these processes, there is a need for the leucocytes to have successful cell molecular interaction. Hence, a combination of molecular interaction and mechanical nature of the leucocytes are a prerequisite for this action to be initiated. To further understand the dynamics of this situation, biophysics can be used to understand the nuances of the situation.
It has been found that the cells carry negative charge on their external surfaces. This leads to the formation of weak colloidal bonds owing to the impact of electrostatic and weak Vander Waals interaction.