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  本篇加拿大论文代写-乳腺癌疫苗开发讲了本研究的目的是了解纳米疫苗在肿瘤标志物的影响人类天门冬氨酰(asparaginyl)β-hydroxylase (HAAH)在乳腺癌的情况下。结果表明,HAAH与细胞异常增殖、运动和转移有关。这是从以前的研究中发现的。基于HAAH是导致癌症进展的主要原因这一范式。研究发现,当这种HAAH被中和时,就有一种中和或抑制癌症进展的作用。抗Haah抗体用于抑制肿瘤的进展。本篇加拿大论文代写文章由加拿大第一论文 Assignment First辅导网整理,供大家参考阅读。

  Fuller, S., Lebowitz, M. and Stewart, S., A cancer therapeutic nanoparticle vaccine targeting HAAH significantly inhibits metastasis in a mouse model of breast cancer. Cancer Research, 75(15 Supplement), 4288-4288 (2015).

  Cancer is a progressive condition. There are currently many researches that have been undertaken to develop vaccines against the development of cancer.

  The purpose of this research was to understand the impact of the nanoparticle vaccine in the tumor marker Human aspartyl (asparaginyl) β-hydroxylase (HAAH) in the case of breast cancer. It was found that HAAH is responsible for the abnormal cell proliferation, its motility and metastasis. This was found from previous research. Based on the paradigm that HAAH is the main causative factor for the progression of the cancer. It was found that when this HAAH gets neutralized, there is a neutralization or inhibition of the cancer progression. Anti Haah antibody is used to inhibit the cancer progressions.

  In this particular research, the N-terminal or C-terminal thirds of HAAH was found to be expression on the λ-phage (200-300 copies). It was found that this anticancer vaccine was able to control and ensure that the anti-HAAH polyclonal antibodies in mice. In the case of HAAH gene, it was found to be different in mice and humans. It was found that the female BALB/c mice were immunized with 10E09 or 10E10 phage particles display the N-terminalor C-terminal of the HAAH. There was a control group that was also used and it did not have any HAAH sequence. The immunization was performed on specific days.

  For this current research, the mouse 4T1 triple-negative breast cancer cell line was used to study the impact of the nanoparticle vaccine. The data generated from the nanoparticle vaccine that targeted the HAAH was found to impede the tumor progression and the metastasis in the mouse model in the breast cancer. The results of the experiment suggested that some of the cancer vaccine development issues were handled in this research.

  This research is an attempt to develop vaccines against breast cancer. The analysis of the HAAH cell lines in mouse has proved that there is potential for developing vaccines against the breast cancer. Future research will be geared towards developing this vaccination on a commercial scale.

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