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温哥华代写:多种药物的耐药性研究分析

当引起肿瘤细胞的各种机制对一种或多种化疗药物表现出耐药性时,就会阻碍化疗的疗效。这被称为多药耐药。在MDR中有几个因素起作用。本研究的重点是通过纳米粒子的协同传递来调节对多种药物的耐药性。本研究综述重点介绍了几种克服MDR机制的纳米药物传递系统。这是通过开发、逃避或中和药物流出泵来实现的。本研究论文具体讨论了五种不同的制度范畴。这些类别是mdr1和survivin靶向、多西他赛和siRNA、紫杉醇和姜黄素、多柔比星和紫杉醇、多柔比星和PSC 833。


温哥华代写:多种药物的耐药性研究分析

需要有效的载体将小干扰的治疗性RNA传递到靶点,这是许多自然挑战需要解决的问题。聚物是一种特殊的生物降解聚合物,由碱敏或酸酯键和氨基酸段组成。这使得PAEs能够在生理pH下冷凝核酸分子,同时在酸性溶酶体或内体环境下通过细胞质释放它们。虽然已经有一些报告将PAEs作为RNA的载体,但是RNAi的效率可能没有预期的那么高。


温哥华代写:多种药物的耐药性研究分析

When various mechanisms in cancer causing cells show resistance towards one or many chemotherapeutics, it hinders the efficacy of chemotherapy. This is referred as multidrug resistance. There are several factors that contribute in MDR. This research specifically focuses on modulate resistance towards multiple drugs by co-delivery of nanoparticle. This research review has highlighted several delivery systems of nanodrug for overcoming the mechanism followed by MDR. This is done by exploiting, evading or neutralizing the pumps of drug efflux. The research essay has specifically discussed about five different system categories. These categories are Mdr-1 and survivin-targeting, Docetaxel and siRNA, Paclitaxel and curcumin, Doxorubicin and paclitaxel and Doxorubicin and PSC 833. Based on the overall discussion, a brief summary is provided.


温哥华代写:多种药物的耐药性研究分析

There is a requirement of efficient carrier for delivering therapeutic RNA of small interference to the site of target as a number of natural challenges have to be dealt with. Poly is a specific biodegradable polymer that consists of base sensitive or acid ester bonds and amino segments. This enables PAEs for condensing the molecules of nucleic acis at physiological pH while releasing them across cytoplasm at acidic lysosomal or endosomal environment. Even though several reports are made to employ PAEs as vehicles of RNA, the efficiency of RNAi may not be as high as per the expectation set.