Assignment First

英国论文代写:血红蛋白巴的静电和氢键

R-state: alpha1Asp94 to beta2Asn102, alpha 1asp94 to beta2Trp37相互作用被取消

消除之间的二聚体排斥之间的阿尔法1 Asp94和阿尔法2 Asp99

侧链之间的盐桥相互作用

英国论文代写:血红蛋白巴的静电和氢键

界面上的四个氢键被削弱了

在二聚体界面形成两个新的r态氢键,一个在-裂隙处

R-state

Hb – Bassett R状态下的4 – 5个直接氢键和2个水介导(HbA: 6个直接氢键和3个水介导)

接触点处的7个h键和盐桥相互作用:变化最小

扭亏

在t态失去一个氢键

英国论文代写:血红蛋白巴的静电和氢键

R-state: alpha 1 Asp94 to beta2Asn102, alpha1Asp94 to beta2Trp37 interactions are abolished
Removal of an interdimer repulsion between alpha 1 Asp94 and beta 2 Asp99
salt-bridge interactions between side chains

英国论文代写:血红蛋白巴的静电和氢键

Four H-bonds at the interface are weakened

Formation of two new hydrogen bonds in R-state at the dimer interface, one at the beta-cleft in
R-state
Four or five direct H-bond and two water-mediated in Hb Bassett R state (compared to HbA: Six direct and three water mediated)
Seven H-bond and salt bridge interactions in T-state at the contact point: change in minimal in
T-state
Loss of one hydrogen bond in T-state